Exploring the HCLS Cloud
The HCLS cloud contains resources from multiple datasets. Navigating this endpoint requires an over all knowledge of what types of things are present and how they are connected. To help simplify the process we have generated a graph summary based on the types of resources present and how they are connected. Each node, ball, represents a distinct entity in the linked data cloud. Arrows between clouds represent a connection that exists between the resource of a particular type and and another resource's type.
To navigate the image use your mouse. Scroll to zoom in and zoom out
The following datasets have been integrated into the HCLS datacloud:
- ChEMBL Database
- Gene Ontology Annotation Database
- Online Mendalian Inheritance in Man (OMIM)
- Comparative Toxicogenomics Database (CTD)
- Side Effects Resource Database (SIDER)
- Cross dataset statistics
The ChEMBL database contains information on medicinal chemicals and related bio assay information. Information covers a wide range of bioassay types including ADMET and binding assays and multiple organisms and targets.
ChEMBL Database Statistics
|How many Compounds in ChEMBL||----||+ show|
|How many Assays in ChEMBL||----||+ show|
|How many Targets in ChEMBL||----||+ show|
|How many Organisms in ChEMBL||----||+ show|
|Types of Assays in ChEMBL||http://hcls.sindice.com/chembl:ADMET|
Gene Ontology Annotation Database
The Gene Ontology Annotation Database (GOA) is a database that revolves around proteins and associated Gene Ontology annotations. The Gene Ontology represents a resource for organizing vocabulary associated with a proteins molecular function, cellular location, and biological process. Annotation of proteins using the Gene Ontology vocabulary enables analysis of shared relationships between sets of genes/proteins based on their defined relations in the ontology.
Gene Ontology Annotation Database Statistics
|Number of Annotations in GOA||----||+ show|
|Number of Genes in GOA||----||+ show|
|Number of Proteins in GOA||----||+ show|
|Number of Organisms in GOA||----||+ show|
Online Mendelian Inheritance in Man (OMIM)
The OMIM database provides information linking genes, diseases, and phenotypes. This information has proved useful in uncovering novel linkages in the disease process.
Online Mendelian Inheritance in Man Database Statistics
|Number of Genes in OMIM||----||+ show|
|Number of Phenotypes in OMIM||----||+ show|
Comparative Toxicogenomics Database (CTD)
The CTD is a database providing linkages between chemical, gene, disease, and pathway information and targets. Each annotation is manually curated by a documented curation process. The goal to aid the investigation into the etiology of disease by understanding the interactions between environmental factors and genes responsible for modulating physiological process.
Comparative Toxicogenomics Database Statistics
|Unique Chemicals in CTD||----||+ show|
|Unique genes in CTD||----||+ show|
|Unique diseases in CTD||----||+ show|
|Unique pathways in CTD||----||+ show|
|Unique chemical-disease relationships in CTD||----||+ show|
|Unique Chemical Gene Interactions in CTD||----||+ show|
|Unique Organisms in CTD||----||+ show|
Side Effects Resource Database (SIDER)
SIDER contains information related to marketed medicines and the frequencies of side effects experienced.
SIDER Database Statistics
|Unique drugs (chemicals) in SIDER||----||+ show|
|Unique side effects in SIDER||----||+ show|
Cross dataset statistics
|Overlap of chemicals between CTD and ChEMBL (based on chembl2mesh mapping file)||----||+ show|
|Overlap of chemicals between SIDER and CTD (based on sider2mesh mapping file)||----||+ show|